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Bettina Sommer

Fri, 08/29/2014 - 10:04 -- Fabrice Berrue
Research Interests:
 
Many Malassezia species are part of the cutaneous microflora commonly found on animals and human. Their presence is often associated with skin disorders, e.g. dandruff and seborrheic dermatitis. Unique for most of the Malassezia species is a lipid-dependency, which can be tracked back on the absence of a fatty acid synthase. Therefore, specific inhibitors for Malassezia lipases are thought to be extremely effective against these organisms.
The project aims to find the natural substrate of the lipases as well as their inhibitors, which are of high value for personal care products as they might be an effective supplement in anti-dandruff formulations.
 
Education:
 
November 2009 University of Regensburg Graduation with diploma (Dipl.-Biol.)

February 2009 – November 2009 Institute of Biophysics and Physical Biochemistry

Diploma thesis “Activation of a chimeric RNA polymerase subunit using directed evolution”

August 2004 – November 2009 Studies in biology at the University of Regensburg. Main focus on biochemistry 

 

Work Experience:

 
December 2013 Technische Universität München Graduation to Dr. rer. nat.

December 2009 – January 2014 Dissertation „A new synthetic biology methodology for the cell-free production of industrial alcohols” doctoral candidate, Industrial Biocatalysis and Chemistry of Biogenic Resources, Technische Universitaet Muenchen

 
Publications:

1, Sommer B, Waege I, Pöllmann D, Seitz T, Thomm M, et al. 2014, Activation of a Chimeric Rpb5/RpoH Subunit Using Library Selection. PLoS ONE 9(1): e87485. doi:10.1371/journal.pone.0087485

2, Sommer B, Garbe D, Schrepfer P, Brück T. 2013. Characterization of a highly thermostable ß-hydroxybutyryl CoA dehydrogenase from Clostridium acetobutylicum ATCC 824. Journal of Molecular Catalysis B: Enzymatic 98: 138-144

3, Sommer B, Haack M, Garbe D, Brück T. 2013. Catalytic Modules in Non-Natural Butanol Biosynthesis: Conversion of the Key Intermediate Crotylalcohol to n-Butanol via a Designed Enzyme Cascade. JSM Biotechnol Bioeng 1(2): 1010

4, Guterl JK, Garbe D, Carsten J, Steffler F, Sommer B, Reisse S, Philipp A, Haack M, Rühmann B, Koltermann A, Kettling U, Brück T, Sieber V.2012. Cell-free metabolic engineering: production of chemicals by minimized reaction cascades. ChemSusChem 5:2165-2172.