Marine Natural Products Lab

Kerr Research Group

David Overy

David Overy

Research Interests:

Acting in a lead role in the Fungal Natural Products Group focused upon the isolation and characterization of fungal strains accessioned into the Marine Natural Products Bank and the fermentation and generation of fungal culture extracts.  Research initiatives include the development of innovative methodologies for fungal isolation and the application of molecular biology tools and various biological assays used to predict the production of novel metabolites and enzymes of interest.  The fungal natural products group is focused upon the discovery of novel antimicrobial compounds, biosurfactants and bioemulsifiers, novel peptides and enzymes for a variety of pharmaceutical, nutraceutical, agricultural and personal care product applications.

Education:

 

PhD, Technical University of Denmark, Kgs. Lyngby, Denmark(2005)
MSc(equivalency), Technical University of Denmark, Kgs. Lyngby, Denmark (2001)
BScHigh Honours in Environmental ScienceCarleton University, Ottawa, Canada (1999)

 

Work Experience:

Adjunct Professor, Department of Pathology and Microbiology, Atlantic Veterinary College, University of PEI (2014 - present)
Senior Research Scientist – Fungal NP Discovery Group LeaderNautilus Bioscience Canada Inc. (2009 - present)
Research Manager, Chemistry Department, University of Prince Edward Island (Dec. 2008 - present)
 
Senior Research Microbiologist, CIBE, Merck Research Laboratories, Merck, Sharp & Dohme de España, Madrid, Spain. (Apr 07 – Oct 2008)
Postdoctoral Researcher, Institute of Biological Sciences, University of Wales, Aberystwyth, UK. (Aug 05 - Apr 07)
Postdoctoral Researcher, Mycology Group, CMB, BioCentrum-DTU, Lyngby, Denmark.(Apr 05 - Jul 05)
PhD student, Mycology Group, CMB, BioCentrum-DTU, Lyngby, Denmark. (Jan 02 - Apr 05)
Researcher, Dept. of Chemistry, University of Canterbury, Christchurch, New Zealand.(Oct 03 - May 04)
Researcher/Sole Proprietor, Myco-Botanical Technologies, Oakville, Ontario, Canada.(Apr 00 - Jan 02)
Diagnostician, Plant Protection Service, Wageningen, Netherlands. (Jul 00 - Nov 00; Mar 01 - Sept 01)
Contract Researcher, ECORC, Agriculture and Agri-Food Canada, Central Experimental Farm, Ottawa, Canada. (June 99 - Mar 00)
Honours Thesis, ECORC, Agriculture and Agri-Food Canada, Ottawa, Canada. (Sept 98 - May 99)
Student Researcher, ECORC, Agriculture and Agri-Food Canada, Ottawa, Canada. (May 98 - Sept. 98)

 

Publications:

Overy DP, Martin C, Muckle A, Lund L, Wood J, Hanna P.  2015.  Cutaneous phaeophyphomycosis caused by Exophiala attenuata in a domestic cat.  Mycopathologia, 180:281-287.

Overy DP, Marron-Lopez F, Muckle A, Bourque A, Lund L, MacHattie D, Lopez A.  2015. Dermatophytosis in farmed mink (Mustela vison) caused by Trichophyton equinum.  Journal of Veterinary Diagnostic Investigation, 27:621-626.

Overy DP, Groman D, Giles J, Duffy S, Rommens M, Johnson G.  2015.  Exophiala angulospora causes systemic mycosis in Atlantic halibut (Hippoglossus hippoglossus): a case report.  Journal of Aquatic Animal Health, 27: 12-19.

Sommer B, Overy DP, Kerr RG.  2015.  Identification and characterization of lipases from Malassezia restricta, a causative agent of dandruffFEMS Yeast Research, 15: fov078.

Herzog B, Overy DP, Haltli B, Kerr RG.  2015.  Discovery of keratinases using bacteria isolated from marine environmentsSystematic and Applied Microbiology, http://dx.doi.org/10.101....

Abd-El-Aziz AS, Agatemor C, Etkin N, Overy DP, Kerr RG.  2015.  Redox-active cationic organoiron complex: a promising lead structure for developing antimicrobial agents with activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.  RSC Advances, 5: 86421-86427.

Abd-El-Aziz AS, Agatemor C, Etkin N, Overy DP, Lanteigne M, McQuillan K, Kerr RG.  2015.  Antimicrobial organometallic dendrimers with tunable activity against multidrug-resistant bacteria.  Biomacromolecules, 16: 3694-3703.

Overy, D.P., Bayman, P., Kerr, R.G., Bills, G.F.  2014.  An assessment of natural products discovery from marine (sensu strictu) and marine-derived fungi.  Mycology, in press.

Overy, D.P., Berrue, F., Correa, H., Hanif, N., Hay, K., Lanteigne, M., McQuilian, K., Duffy, S., Boland, P., Jagannathan, R., Carr, G.S., Vansteeland, M., Kerr, R.G.  2014.  Sea foam as a source of fungal inoculum for the isolation of biologically active natural products.  Mycology, in press.

Overy, D.P., Groman, D., Giles, J., Duffy, S., Johnson, G.  2014.  Exophiala angulospora causes systemic mycosis in Atlantic halibut (Hippoglossus hippoglossus) – A case report.  J. Aquat. Anim. Health, accepted.

Khankhet, J., Vanderwolf, K.J., McAlpine, D.F., McBurney, S., Overy, D.P., Slavic, D., Xu, J.  2014.  Clonal expansion of the Pseudogymnoascus destructans genotype in North America is accompanied by significant variation in phenotypic expression. PLOS ONE, accepted.

Marchal, E., Uddin, Md.I., Smithen, D.A., Hawco, L.A., Lanteigne, M., Overy, D.P., Kerr, R.G., Thompson, A.  2013.  Antimicrobial activity of non-natural prodigiosenes.  RSC Advances, 3: 22967-22971.

Ebead, G.A., Overy, D.P., Berrue, F., Kerr, R.G. 2012. Westerdykella reniformis sp. nov., producing the antibiotic metabolites melinacidin IV and chetracin BIMA Fungus3: 189-201.

Houbraken, J., Frisvad, J.C., Siefert, K.A., Overy, D.P., Tuthill, D.M., Valdez, J.G., Samson, R.A. 2012. New penicillin-producing Penicillium species and an overview of section ChrysogenaPersoonia29: 78-100.

Pelaez, F., Collado, J., Platas, G., Overy, D.P., Martin, J., Vicente, F., Gonzalez del Val, A., Basilio, A., De la Cruz, M., Tormo, J.R., Fillola, A., Arenal, F., Villareal, M., Rubio, V., Baral, H.O., Galan, R., Bills, G.F. 2011. Phylogeny and intercontinental distribution of the pneumocandin-producing anamorphic fungus Glarea lozoyensisMycology2: 1-17.

Beckmann, M., Enot, D.P., Overy, D.P., Scott, I., Jones, P., Allaway, D., and Draper, J.  2010. Metabolite fingerprinting of urine suggests breed-specific dietary metabolism differences in domestic dogs.  British Journal of Nutrition103:1127-1138.

Overy, D.P., Calati, K., Nielsen Kahn, J., Hsu, M., Martin, J., Collado, J., Roemer, T., Harris, G., Parish, C. 2009. Isolation and structure elucidation of parnafungins C and D, isoxazolidinone-containing antifungal natural productsBioorganic & Medicinal Chemistry Letters19: 1224-1227.
 
Bills, G.F., Platas, G., Overy, D.P., Collado, J., Fillola, A., Jimenez, M.R., Martin, J., Gonzalez del Val, A., Vicente, F., Tormo, J.R., Pelaez, F., Calati, K., Harris, G., Parish, C., Xu, D., Roemer, T. 2009. Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungiMycologia101: 445-468.
 
Bills, G.F., Overy, D.P., Genilloud, O. and Peláez, F. 2009. Contributions of pharmaceutical antibiotic and secondary metabolite discovery to the understanding of microbial defence and antagonism. In: Defensive Mutualism in Microbial Symbiosis. Editors J. White and M.S. Torres, Marcel Dekker, New York. (in press)
 
Overy, D.P., Enot, D.P., Tailliart, K., Jenkins, H., Parker, D., Beckmann, M. and Draper, J. 2008. Explanatory signal interpretation and metabolite identification strategies for nominal mass FIE-MS metabolite fingerprintsNature Protocols3: 471-485.
 
Enot, D.P., Wanchang, L., Beckmann, M., Parker, D., Overy, D.P. and Draper, J. 2008.  Preprocessing, classification modelling and feature selection using flow injection elcetrospray mass spectrometry metabolite fingerprint dataNature Protocols3: 446-470.
 
Parker, D., Beckmann, M., Enot, D.P., Overy, D.P., Caracuel Rios, Z., Gilbert, M., Talbot, N. and Draper, J. 2008.  Rice blast infection of Brachypodium distachyon as a model system to study dynamic host/pathogen interactionsNature Protocols3: 435-445.
 
Beckmann, M., Enot, D.P., Overy, D.P. and Draper, J. 2007. Representation, comparison, and interpretation of metabolome fingerprint data for total composition analysis and quality trait investigation in potato cultivars. Journal of Agricultural and Food Chemistry55: 3444-3451.
 
Enot, D.P., Beckmann, M., Overy. D.P., Draper, J. 2006. Predicting interpretability of metabolome models based on behavior, putative identity, and biological relevance of explanatory signals. Proceedings of the National Academy of Science, USA.103:14865-14870.
 
Overy, D.P., Smedsgaard, J., Frisvad, J.C. and Thrane, U. 2006. Host-derived media used as a predictor for low abundant, in planta metabolite production from necrotrophic fungi.  Journal of Applied Microbiology101: 1292-1300.
 
Overy, D.P., Phipps, R., Frydenvang, K. and Larsen,T.O. 2006. epi-Neoxaline, a chemotaxonomic marker for Penicillium tulipaeBiochemical Systematics and Ecology34: 345-348.
 
Frisvad, J.C., Larsen, T.O., Dalsgaard, P.W., Lyhne, E.K., Jarvis, B.B., Fettinger, J.C., Seifert, K.A., Louis-seize, G. and Overy, D.P. 2006. Four psychrotolerant species with high chemical diversity consistently producing cycloaspeptide, Penicillium jamesonlandense sp. nov., P. ribeum sp. nov, P. soppii and P. lanosumInternational Journal of Systematic and Evolutionary Microbiology56: 1427-1437.
 
Valdez, J.G., Makuch, M.A., Ordovini, A.F., Masuelli, R.W., Overy, D.P. and Piccolo,R.J. 2006. Penicillium allii, responsible for blue mold rot in garlic in the Mendoza and San Juan provinces of Argentina. Plant Disease55: 583.
 
Valdez, J.G., Makuch, M.A., Ordovini, A.F., Masuelli, R.W., Overy, D.P. and Piccolo,R.J. 2006. First report of Penicillium allii as a field pathogen of garlic (Allium sativum)Plant Pathology55: 583.
                            
Overy, D.P. and Frisvad, J.C. 2005. Mycotoxin production and post harvest storage rot of Zingiber officinale by Pencillium brevicompactumJournal of Food Protection68:607-609.
 
Overy, D.P., Frisvad, J.C., Steinmeier, U. and Thrane, U. 2005. Clarification of the agents causing blue mould storage rot upon various flower and vegetable bulbs: implications for mycotoxin contaminationPostharvest Biology and Technology35: 217-221.
 
Overy, D.P., Karlshøj, K. and Due, M.J. 2005. Temperature and enzymatic profiling of taxa from the Penicillium series Corymbifera; species responsible for blue mould storage rot in bulbs.  Journal of Plant Pathology87: 53-59.
 
Overy, D.P., Larsen, T.O., Dalsgaard, P.W., Frydenvang, K., Phipps, R., Monro, M and Christopherson, C. 2005. Andrastin A and barceloneic metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implicationsMycological Research11: 1243-1249.
 
Overy, D.P., Nielsen, K.F. and Smedsgaard, J. 2005. Roquefortine/oxaline biosynthesis pathway metabolites in Penicillium ser. Corymbiferain planta production and implications for competitive fitness. Journal of Chemical Ecology31: 2375-2392.
 
Overy, D.P., Valdez, J.G. and Frisvad, J.C. 2005. Revisions to the Penicillium series Corymbifera: agents responsible for blue mold storage rot of various flower and vegetable bulbs.  Canadian Journal of Botany83: 1422-1433.
 
Overy, D.P., Zidorn, C.H.W., Petersen, B.O., Duus, J.Ø., Dalsgaard, P.W., Larsen, T.O. and Phipps, R. 2005. Medium dependant production of corymbiferone, a novel metabolite from Penicillium hordei cultured on plant tissue agarTetrahedron Letters46: 3225-3228.
 
Overy, D.P. and Blunt, J.W. 2004. Corymbiferan lactones from Penicillium hordei: stimulation of novel phenolic metabolites using plant tissue media. Journal of Natural Products67: 1850-1853.
 
Overy, D.P. and Frisvad, J.C. 2003. New Penicillium species associated with bulbs and root vegetables. Systematic and Applied Microbiology 26: 631-639.
 
Overy, D.P, Seifert, K., Savard, M.E., Frisvad, J.C. 2003. Spoilage fungi and their mycotoxins in commercially marketed chestnuts. International Journal of Food Microbiology 88: 69-77.