Marine Natural Products Lab

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Doug Marchbank

Tue, 06/09/2015 - 09:12 -- Patricia Boland
Research Interests:
 
My research is primarily focused on the discovery and development of natural products with a range of applications in human health and wellness. Our team utilizes a LC/MS-based metabolomics approach to profile microbial extracts and identify potentially novel compounds through statistical analysis. This work also includes purification and structure elucidation of natural products and characterization of their properties. My efforts are also focused on the synthesis of natural product analogues to expand our knowledge of structure-activity relationships and develop new lead compounds. As a senior chemist with Nautilus Biosciences, I am interested in the development of organic UV filters, biosurfactants, antimicrobials, and antioxidants.
 
Education:
 
PhD, University of Prince Edward Island (2013)
BSc (Hons) in Chemistry, University of Prince Edward Island (2008)
 
Work Experience:
Research Manager, Chemistry Department, University of Prince Edward Island (2015 - present)
Senior Scientist, Nautilus Biosciences Canada Inc., Charlottetown, PE, Canada (2015 - present)
Research Assistant, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada (2014 - 2015)
Postdoctoral Fellow, University of Prince Edward Island (2013)
 
Publications:
McCulloch, M.W.B.; Haltli, B.H.; Marchbank, D.H.; Kerr, R.G. Evaluation of pseudopteroxazole and pseudopterosin derivatives against Mycobacterium tuberculosis and other pathogens. Mar. Drugs 2012, 10, 1711-1728.
Marchbank, D.H.; Berrue, F.; Kerr, R.G. Eunicidiol, an anti-inflammatory dilophol diterpene from Eunicea fusca. J. Nat. Prod. 2012, 75, 1289-1293.
Marchbank, D.H.; Kerr, R.G. Semisynthesis of fuscoside B analogues and eunicosides, and analysis of anti-inflammatory activity. Tetrahedron 2011, 67, 3053-3061.